Properties of arabinonucleic acids (ANA & 20'F-ANA): implications for the design of antisense therapeutics that invoke RNase H cleavage of RNA.

Abstract

Inversion of configuration of the C2' position of RNA leads to a very unique nucleic acid structure: arabinonucleic acid (ANA). ANA, and its 2'-fluoro derivative (2'F-ANA) from hybrids with RNA that are capable of activating RNase H, resulting in cleavage of the RNA strand. In this paper, we review the properties of duplexes formed between ANA (or 2'F-ANA) and its RNA complement. These studies support the notion that RNase H is sensitive to the minor groove dimensions of the hybrid substrate.

Cite this paper

@article{Damha2001PropertiesOA, title={Properties of arabinonucleic acids (ANA & 20'F-ANA): implications for the design of antisense therapeutics that invoke RNase H cleavage of RNA.}, author={Masad J Damha and Anne Marie Noronha and Christopher J Wilds and Jean Francois Trempe and Alexei Yu Denisov and Richard Pon and Kalle Gehring}, journal={Nucleosides, nucleotides & nucleic acids}, year={2001}, volume={20 4-7}, pages={429-40} }