Properties of alpha-dehydrobiotin-resistant mutants of Escherichia coli K-12.

  title={Properties of alpha-dehydrobiotin-resistant mutants of Escherichia coli K-12.},
  author={M A Eisenburg and Brian J Mee and Om Prakash and M R Eisenburg},
  journal={Journal of bacteriology},
  volume={122 1},
We have isolated four classes of mutants resistant to alpha-dehydrobiotin, a biotin analogue. One mutant group, referred to as bioR shows high excretion levels of biotin vitamers, derepressed levels of the biotin biosynthetic enzymes, and resistance to repression by biotin. The mutation has been mapped between argC and bfe at min 79. A second class of mutants, with lesions in the bioA operon at min 17.5, shows derepressed levels of the dethiobiotin synthetase enzyme and has been tentatively… CONTINUE READING

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