Properties of adenosine-triphosphate-regulated potassium channels in guinea-pig ventricular cells.

@article{Kakei1985PropertiesOA,
  title={Properties of adenosine-triphosphate-regulated potassium channels in guinea-pig ventricular cells.},
  author={Masafumi Kakei and Akinori Noma and Tohru Shibasaki},
  journal={The Journal of physiology},
  year={1985},
  volume={363},
  pages={
          441-62
        }
}
A class of K channels in cardiac muscle is reversibly blocked by intracellular adenosine 5'-triphosphate (ATP). The characteristics of this K channel were studied by recording single-channel currents in ventricular cells isolated enzymatically from guinea-pig heart. The reversal potential of single-channel currents agreed well with the K equilibrium potential. Blockers of other K channels, such as tetraethylammonium and 4-aminopyridine, decreased the mean open time of the channel. The chord… CONTINUE READING

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