Properties of a kappa-opioid receptor expressed in CHO cells: interaction with multiple G-proteins is not specific for any individual G alpha subunit and is similar to that of other opioid receptors.

@article{Prather1995PropertiesOA,
  title={Properties of a kappa-opioid receptor expressed in CHO cells: interaction with multiple G-proteins is not specific for any individual G alpha subunit and is similar to that of other opioid receptors.},
  author={Paul L. Prather and Therese M McGinn and P A Claude and Lee-Yuan Liu-Chen and Horace H. Loh and Ping-Yee Law},
  journal={Brain research. Molecular brain research},
  year={1995},
  volume={29 2},
  pages={336-46}
}
The purpose of the present study was to examine the coupling pattern of a recently cloned kappa-opioid receptor stably transfected in CHO cells to individual G alpha subunits with subsequent comparison to that observed previously for delta- and mu-opioid receptors. Data presented in the current study indicate the successful stable expression of a kappa-opioid receptor in CHO cells. This is supported by experiments in which ligands with selectivity for kappa-, but not delta- or mu-opioid… CONTINUE READING
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