Properties of a Distinct Subpopulation of GABAergic Commissural Interneurons That Are Part of the Locomotor Circuitry in the Neonatal Spinal Cord

@article{Wu2011PropertiesOA,
  title={Properties of a Distinct Subpopulation of GABAergic Commissural Interneurons That Are Part of the Locomotor Circuitry in the Neonatal Spinal Cord},
  author={Linying Wu and Patrick M. Sonner and David J Titus and Erik P. Wiesner and Francisco J. Alvarez and Lea Ziskind-Conhaim},
  journal={The Journal of Neuroscience},
  year={2011},
  volume={31},
  pages={4821 - 4833}
}
Commissural inhibitory interneurons (INs) are integral components of the locomotor circuitry that coordinate left–right motor activity during movements. We have shown that GABA-mediated synaptic transmission plays a key role in generating alternating locomotor-like activity in the mouse spinal cord (Hinckley et al., 2005a). The primary objective of our study was to determine whether properties of lamina VIII (LVIII) GABAergic INs in the spinal cord of GAD67::GFP transgenic mice fit the… 

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References

SHOWING 1-10 OF 77 REFERENCES

Locomotor-like rhythms in a genetically distinct cluster of interneurons in the mammalian spinal cord.

It is suggested that the visually identified HB9/GFP interneurons are premotor excitatory interneuronons and putative constituents of networks generating locomotor rhythms in the mammalian spinal cord.

Intrinsic and Functional Differences among Commissural Interneurons during Fictive Locomotion and Serotonergic Modulation in the Neonatal Mouse

It is suggested that dCINs and aCins, but not adCINS, are excited by 5-HT and are rhythmically active during fictive locomotion, which may play important roles in the coordination of left–right limb movements during locomotion.

Transmitter‐phenotypes of commissural interneurons in the lumbar spinal cord of newborn mice

The results suggest that glycinergic, GABAergic, and glutamatergic CINs are the principal CIN phenotypes in the CPG region of the lumbar spinal cord in the newborn mouse.

Electrical Coupling between Locomotor-Related Excitatory Interneurons in the Mammalian Spinal Cord

The finding that electrical transmission persists in mice that can walk is indicative of its importance in coordinating the activity of this neuronal population in functionally mature spinal networks.

Segmental, Synaptic Actions of Commissural Interneurons in the Mouse Spinal Cord

The study suggests that, based on observed synaptic connectivity, both short- and long-range CINs are likely involved in segmental left–right coordination and that the CIN system is organized into a dual-inhibitory and single-excitatory system.

Serotonin modulates the properties of ascending commissural interneurons in the neonatal mouse spinal cord.

The hypothesis that aCINs play important roles in coordinating left-right movements during fictive locomotion and thus may be component neurons in the locomotor CPG in neonatal mice is supported.

Synaptic targets of commissural interneurons in the lumbar spinal cord of neonatal rats

The results suggest that commissural interneurons may establish monosynaptic contacts with motor neurons on the opposite side of the spinal cord and indicate that direct reciprocal connections between commissures on the two sides ofThe spinal cord may also exist.

Synaptic integration of rhythmogenic neurons in the locomotor circuitry: the case of Hb9 interneurons

The findings suggest that the rhythmogenic Hb9 INs are integral components of the sensorimotor circuitry that regulate locomotor‐like activity in the spinal cord.

Projection patterns of commissural interneurons in the lumbar spinal cord of the neonatal rat

The results provide an anatomical framework for further electrophysiological studies aimed at identifying the CINs that participate in the mammalian locomotor central pattern generator.

Electrophysiological Characterization of V2a Interneurons and Their Locomotor-Related Activity in the Neonatal Mouse Spinal Cord

Earlier proposals that the V2a interneurons are components of the hindlimb central pattern generator, helping to organize left–right locomotor coordination in the neonatal mouse spinal cord are reinforced.
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