Properties of a Distinct Subpopulation of GABAergic Commissural Interneurons That Are Part of the Locomotor Circuitry in the Neonatal Spinal Cord

  title={Properties of a Distinct Subpopulation of GABAergic Commissural Interneurons That Are Part of the Locomotor Circuitry in the Neonatal Spinal Cord},
  author={Linying Wu and Patrick M. Sonner and David J Titus and Erik P. Wiesner and Francisco J. Alvarez and Lea Ziskind-Conhaim},
  journal={The Journal of Neuroscience},
  pages={4821 - 4833}
Commissural inhibitory interneurons (INs) are integral components of the locomotor circuitry that coordinate left–right motor activity during movements. We have shown that GABA-mediated synaptic transmission plays a key role in generating alternating locomotor-like activity in the mouse spinal cord (Hinckley et al., 2005a). The primary objective of our study was to determine whether properties of lamina VIII (LVIII) GABAergic INs in the spinal cord of GAD67::GFP transgenic mice fit the… 

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