Properties of Yersinia enterocolitica porins: interference with biological functions of phagocytes, nitric oxide production and selective cytokine release.

@article{Tufano1994PropertiesOY,
  title={Properties of Yersinia enterocolitica porins: interference with biological functions of phagocytes, nitric oxide production and selective cytokine release.},
  author={Maria Antonietta Tufano and Fabio Rossano and Piergiorgio Catalanotti and Giuseppina Liguori and Andreas Marinelli and Adone Baroni and Paolo Marinelli},
  journal={Research in microbiology},
  year={1994},
  volume={145 4},
  pages={297-307}
}
We have extracted and purified Yersinia enterocolitica ATCC 9610 porins that have molecular weights of 36-38 kDa. They inhibited phagocytosis and phagosome-lysosome fusion (30%) in human monocytes and caused enhanced nitrite production. Preincubation of polymorphonuclear neutrophils with porins (1-10 micrograms/ml/10(6) cells) induced a reduction in chemotaxis, adherence to nylon wool and chemiluminescence. Human lymphomonocytes treated with Y. enterocolitica porins showed a distinctive… CONTINUE READING