Properties of Local Interactions and Their Potential Value in Complementing Genome-Wide Association Studies

@inproceedings{Wei2013PropertiesOL,
  title={Properties of Local Interactions and Their Potential Value in Complementing Genome-Wide Association Studies},
  author={Wenhua Wei and Attila Gyenesei and C. A. M. Semple and Chris S. Haley},
  booktitle={PloS one},
  year={2013}
}
Local interactions between neighbouring SNPs are hypothesized to be able to capture variants missing from genome-wide association studies (GWAS) via haplotype effects but have not been thoroughly explored. We have used a new high-throughput analysis tool to probe this underexplored area through full pair-wise genome scans and conventional GWAS in diastolic and systolic blood pressure and six metabolic traits in the Northern Finland Birth Cohort 1966 (NFBC1966) and the Atherosclerosis Risk in… CONTINUE READING

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