Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias.

@article{Chouabe1997PropertiesOK,
  title={Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias.},
  author={Christophe Chouabe and Nathalie Neyroud and Pascale Guicheney and Michel Lazdunski and Georges Romey and Jacques Barhanin},
  journal={The EMBO journal},
  year={1997},
  volume={16 17},
  pages={5472-9}
}
Mutations in the delayed rectifier K+ channel subunit KvLQT1 have been identified as responsible for both Romano-Ward (RW) and Jervell and Lange-Nielsen (JLN) inherited long QT syndromes. We report the molecular cloning of a human KvLQT1 isoform that is expressed in several human tissues including heart. Expression studies revealed that the association of KvLQT1 with another subunit, IsK, reconstitutes a channel responsible for the IKs current involved in ventricular myocyte repolarization. Six… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
87 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 87 extracted citations

Similar Papers

Loading similar papers…