Properties of Human Mitochondrial Ribosomes

@article{Obrien2003PropertiesOH,
  title={Properties of Human Mitochondrial Ribosomes},
  author={T. W. O'brien},
  journal={IUBMB Life},
  year={2003},
  volume={55}
}
Mammalian mitochondrial ribosomes (55S) differ unexpectedly from bacterial (70S) and cytoplasmic ribosomes (80S), as well as other kinds of mitochondrial ribosomes. Typical of mammalian mitochondrial ribosomes, the bovine mitochondrial ribosome has been developed as a model system for the study of human mitochondrial ribosomes, to address several questions related to the structure, function, biosynthesis and evolution of these interesting ribosomes. Bovine mitochondrial ribosomal proteins (MRPs… Expand
Nuclear MRP genes and mitochondrial disease.
TLDR
This manuscript reviews the distinctive properties of human mitochondrial ribosomes and ribosomal proteins, and the correlation of MRP3 gene locations with loci associated with disorders of energy metabolism, and provides localization information for one of the unusual proteins contained in human mitochondrial Ribosomes, MRPS29. Expand
Structure of the large ribosomal subunit from human mitochondria
TLDR
The structure of the human mitochondrial ribosome reveals how it is adapted to synthesize mitochondrial membrane proteins and unveils an adaptation of the exit tunnel for hydrophobic nascent peptides and extensive remodeling of the central protuberance. Expand
The discovery of mitochondrial ribosomes
Observations leading to the discovery of mitochondrial ribosomes are recounted.  Mammalian mitochondrial ribosomes, the first to be discovered (O’Brien and Kalf, 1967 a,b), are 55S ribosomes, with aExpand
Mitochondrial ribosome assembly in health and disease
TLDR
This article focuses on summarizing the current available information on mitoribosome assembly pathway, factors that form the mitoribergsome assembly machinery, and the effect of defective mitorIBosomeAssembly assembly on human health. Expand
Regulatory Roles of Mitochondrial Ribosome in Lung Diseases and Single Cell Biology.
TLDR
The structure, elements, functions, and regulatory roles in associated diseases, including mitochondrial ribosomal RNA (mt-rRNA) variations can affect the mitochondria in developing disease are summarized. Expand
Import of ribosomal proteins into yeast mitochondria.
TLDR
This review article summarizes the current knowledge on the transport of proteins into the mitochondrial matrix, and thereby specifically focus on proteins of the mitochondrial ribosome. Expand
Trypanosoma brucei Mitochondrial Ribosomes
Although eukaryotic mitochondrial (mt) ribosomes evolved from a putative prokaryotic ancestor their compositions vary considerably among organisms. We determined the protein composition of tandemExpand
RSM22, mtYsxC and PNKD-like proteins are required for mitochondrial translation in Trypanosoma brucei.
TLDR
It is shown that all three proteins are important for the growth of T. brucei and play an important function in mitochondrial translation, as their ablation by RNAi rapidly and severely affected the de novo synthesis of mitochondrial proteins. Expand
Reconstructing the evolution of the mitochondrial ribosomal proteome
TLDR
The evolutionary history of the mitoribosomal proteome is reconstructed, revealing an ancestral ribosome of alpha-proteobacterial descent that more than doubled its protein content in most eukaryotic lineages. Expand
Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins
TLDR
The main steps of ribosome biogenesis alterations occurring during tumorigenesis are summarized, highlighting the changes in the expression level of cytosolic ribosomal proteins (CRPs) and mitochondrial ribosom proteins (MRPs) in different types of tumors. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 35 REFERENCES
[22] Bovine mitochondrial ribosomes
TLDR
The bovine mitochondrial ribosome is being developed as a model system for studying the structure and function of mammalian mitochondria, and its large number of proteins raises questions about their functional and structural organization. Expand
Mitochondrial ribosomal proteins (MRPs) of yeast.
TLDR
Surprisingly, only a minority of the MRPs that have been characterized show significant sequence similarities to known ribosomal proteins from other sources, thus limiting the deduction of their functions by simple comparison of amino acid sequences. Expand
Structure and Function of Mammalian Mitochondrial Ribosomes
The discovery of ribosomes in mitochondria (O’Brien and Kalf, 1967) foreshadowed the surprising diversity of ribosome types in nature. The 55S ribosomes from mammalian mitochondria resemble bacterialExpand
The general occurrence of 55 S ribosomes in mammalian liver mitochondria.
  • T. W. O'brien
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1971
TLDR
Dissociation studies show that the 55 S ribosome is a mitochondrial monosome, composed of a 28 S small subunit and a 39 S subunit, and these mammalian 55 S mitochondrial ribosomes are the smallest monosomes known. Expand
Evolution of proteins in mammalian cytoplasmic and mitochondrial ribosomes
TLDR
It is significant that mammalian mitochondrial r- Proteins are evolving more rapidly than cytoplasmic r-proteins in the same cell, since both sets of r-Protein are encoded by nuclear genes. Expand
Mammalian Mitochondrial Ribosomal Proteins
TLDR
To identify mammalian mitochondrial ribosomal proteins and their corresponding genes, mature rat MRPs were purified and 12 different N-terminal amino acid sequences were determined and screened for corresponding DNA sequences to identify the genes or to establish consensus cDNAs. Expand
Structural Compensation for the Deficit of rRNA with Proteins in the Mammalian Mitochondrial Ribosome
TLDR
The results showed that the proteins with binding sites on rRNA shortened or lost in the mitoribosome were enlarged when compared with the E. coli counterparts; this suggests the structural compensation of the rRNA deficit by the enlarged proteins in themitorIBosome. Expand
Protein composition of the bovine mitochondrial ribosome.
The protein complement of the bovine mitochondrial ribosome has been analyzed by two-dimensional electrophoresis in polyacrylamide gels to determine the number and molecular weights of the ribosomalExpand
Physiochemical Properties of Rat Liver Mitochondrial Ribosomes*
TLDR
Measurements of solvation suggest that ribosomes are highly hydrated structures, also in agreement with current models depicting ribosome as porous structures containing numerous gaps and tunnels. Expand
Ribosomes from rat liver mitochondira. II. Partial characterization.
TLDR
The 55 S particle probably represents the monomeric form of the mitochondrial ribosome because it is isolated as the major ribosomal component and attain a specific radioactivity 50 times that of the total mitochondrial protein when mitochondria are pulse labeled with 14C-leucine for 5 min in vitro. Expand
...
1
2
3
4
...