Properties of GABAA receptors underlying inhibitory synaptic currents in neocortical pyramidal neurons.

@article{Galarreta1997PropertiesOG,
  title={Properties of GABAA receptors underlying inhibitory synaptic currents in neocortical pyramidal neurons.},
  author={M. A. G. V. Galarreta and Shaul Hestrin},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 19},
  pages={7220-7}
}
Rapid applications of GABA (from 10 microM to 10 mM) to outside-out patches were used to study the role that the kinetic properties of GABAA receptors play in determining the time course of IPSCs in neocortical pyramidal neurons. Currents induced by rapid applications of brief (1 msec) pulses of GABA (1 mM) showed a biexponential decay phase that seems to involve the entry of GABAA receptors into desensitized states. This conclusion is based on the similar fast decay kinetics of the response to… CONTINUE READING
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