Properties of 4-ethenyl and 4-ethynyl analogs of pyridoxal phosphate and their reactions with the apo form of asparatate aminotransferase.

Abstract

The binding to apoaspartate aminotransferase of analogs of pyridoxal phosphate bearing vinyl, cis- and trans-methylvinyl, and ethynyl groups in place of the fomyl group of the coenzyme has been studied. Details of synthesis of the ethynyl compound are given. The absorption spectra of all of the compounds have been analyzed and pKa values have been… (More)

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@article{Yang1975PropertiesO4, title={Properties of 4-ethenyl and 4-ethynyl analogs of pyridoxal phosphate and their reactions with the apo form of asparatate aminotransferase.}, author={Isabel Y. Yang and Constance Harris and David E Metzler and Walter Korytnyk and Bodo Lachmann and P P Potti}, journal={The Journal of biological chemistry}, year={1975}, volume={250 8}, pages={2947-55} }