Properties of 3-hydroxy-3-methylglutaryl coenzyme A reductase solubilized from rat liver and hepatoma.

@article{Brown1974PropertiesO3,
  title={Properties of 3-hydroxy-3-methylglutaryl coenzyme A reductase solubilized from rat liver and hepatoma.},
  author={Michael Sean Brown and Steven Dana and MarvinD. Siperstein},
  journal={The Journal of biological chemistry},
  year={1974},
  volume={249 20},
  pages={
          6585-9
        }
}
SUMMARY In hepatomas, the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-controlling enzyme in cho- lesterol biosynthesis, is not normally suppressed by choles- terol. To examine the biochemical mechanism of this loss of feedback control of cholesterol synthesis, a comparison was made of the properties of 3-hydroxy-3-methylglutaryl coenzyme A reductase after solubilization and partial purifi- cation from microsomes of normal rat liver and of a minimal deviation rat… CONTINUE READING

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