Properties of 2'-fluorothymidine-containing oligonucleotides: interaction with restriction endonuclease EcoRV.

@article{Williams1991PropertiesO2,
  title={Properties of 2'-fluorothymidine-containing oligonucleotides: interaction with restriction endonuclease EcoRV.},
  author={D. Williams and F. Benseler and F. Eckstein},
  journal={Biochemistry},
  year={1991},
  volume={30 16},
  pages={
          4001-9
        }
}
2'-Fluorothymidine (Tf) was synthesized via an improved procedure with (diethylamino)sulfur trifluoride. The compatibility of the analogue with DNA synthesis via the phosphoramidite method was demonstrated after complete enzymatic digestion of the oligonucleotides d(Tf11T) and d(Tf3T), the sole products of which were 2'-fluorothymidine and thymidine in the expected ratio. The 2'-fluorothymidine was also incorporated into the EcoRV recognition sequence (underlined), within the complementary… Expand
Synthesis and properties of 2'-deoxy-2',4'-difluoroarabinose-modified nucleic acids.
Selection of 2'-Fluoro-Modified Aptamers with Optimized Properties.
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