Properties and potential of ertapenem.

  title={Properties and potential of ertapenem.},
  author={David Martin Livermore and Armine M Sefton and Geoffrey M. Scott},
  journal={The Journal of antimicrobial chemotherapy},
  volume={52 3},
Ertapenem is a carbapenem that shares the activity of imipenem and meropenem against most species, but is less active against non-fermenters. Activity is retained against most strains with AmpC and extended-spectrum beta-lactamases, although resistance can arise if these enzymes are combined with extreme impermeability. Resistance can also be caused by IMP, VIM, KPC and NMC carbapenemases, but again, co-requires impermeability. Although the spread of carbapenemases in the future is a concern… CONTINUE READING