Properties and malignant transformation of established rat liver parenchymal cells in culture.

@article{Borenfreund1975PropertiesAM,
  title={Properties and malignant transformation of established rat liver parenchymal cells in culture.},
  author={Ellen Borenfreund and Paul J. Higgins and Mildred Steinglass and Aaron Bendich},
  journal={Journal of the National Cancer Institute},
  year={1975},
  volume={55 2},
  pages={375-84}
}
Epithelioid cells from the livers of normal and genetically impaired (Gunn) rats were established in long-term cultures in vitro. These cells grew as flat, epithelioid cobble-stone-type monolayers and showed a diploid karyotype. They secreted rat serum albumin and proteins into their growth media and contained aryl hydrocarbon hydroxylase. Such cells were transformed by treatment with methylazoxymethanol acetate; they then exhibited an irregular, piling growth pattern, acquired the ability to… CONTINUE READING
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