Properties and functions of a neuromedin-B-preferring bombesin receptor in brain microvascular endothelial cells.

@article{Vigne1995PropertiesAF,
  title={Properties and functions of a neuromedin-B-preferring bombesin receptor in brain microvascular endothelial cells.},
  author={P. Vigne and E Feolde and C van Renterghem and J. P. Breittmayer and Christian Frelin},
  journal={European journal of biochemistry},
  year={1995},
  volume={233 2},
  pages={
          414-8
        }
}
  • P. Vigne, E Feolde, +2 authors Christian Frelin
  • Published in
    European journal of…
    1995
  • Biology, Medicine
  • Endothelial cells were isolated from rat brain microvessels and grown in vitro. They expressed a high density of [125I-Tyr4]bombesin receptor (Bmax = 0.9 pmol/mg protein) with an apparent Kd value of 10 nM. The pharmacological profile of inhibition of the specific [125I-Tyr4]bombesin binding [bombesin = neuromedin B > gastrin releasing peptide (GRP)] was consistent with the presence of a neuromedin-B-preferring receptor. Addition of bombesin, neuromedin B and GRP increased the activity of… CONTINUE READING

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