Properties and function of heparanase in cancer metastasis and angiogenesis.

@article{Vlodavsky2001PropertiesAF,
  title={Properties and function of heparanase in cancer metastasis and angiogenesis.},
  author={Israel Vlodavsky and Orit Goldshmidt},
  journal={Haemostasis},
  year={2001},
  volume={31 Suppl 1},
  pages={60-3}
}
Cleavage of heparan sulfate proteoglycans affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular microenvironment. Heparanase, degrading heparan sulfate (HS) at specific intrachain sites, is synthesized as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. The heparanase enzyme is preferentially… CONTINUE READING
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