Properties and function of KCNQ1 K+ channels isolated from the rectal gland of Squalus acanthias

@article{Kerst2001PropertiesAF,
  title={Properties and function of KCNQ1 K+ channels isolated from the rectal gland of Squalus acanthias},
  author={Gunter Kerst and Ulrich Beschorner and Bernhard W. Uns{\"o}ld and Thomas Hahn and Rainer Schreiber and Rainer Greger and Uwe Gerlach and Hans -Georg Lang and Karl Kunzelmann and Markus Bleich},
  journal={Pfl{\"u}gers Archiv},
  year={2001},
  volume={443},
  pages={146-154}
}
KCNQ1 (KVLQT1) K+ channels play an important role during electrolyte secretion in airways and colon. KCNQ1 was cloned recently from NaCl-secreting shark rectal glands. Here we study the properties and regulation of the cloned sKVLQT1 expressed in Xenopus oocytes and Chinese hamster ovary (CHO) cells and compare the results with those obtained from in vitro perfused rectal gland tubules (RGT). The expression of sKCNQ1 induced voltage-dependent, delayed activated K+ currents, which were augmented… CONTINUE READING