Properties and developmental regulation of polysialyltransferase activity in the chicken embryo brain.

@article{Oka1995PropertiesAD,
  title={Properties and developmental regulation of polysialyltransferase activity in the chicken embryo brain.},
  author={Saori Oka and Juan L. Brus{\'e}s and Randall W. Nelson and U. S. Rutishauser},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 33},
  pages={
          19357-63
        }
}
The properties and developmental regulation of vertebrate polysialyltransferase (PST), an enzyme activity responsible for extension of alpha 2,8-linked sialic acid homopolymers (PSA) associated with the fifth Ig domain of the neural cell adhesion molecule (NCAM). have been studied. The assay for PST used exogenous NCAM as a substrate, with a PSA-specific endoneuraminidase as a control for specificity. Optimal conditions for PST activity at 37 degrees C were found to be pH 6.0 in the presence of… CONTINUE READING
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