Properties and biotechnological applications of natural and engineered haloalkane dehalogenases

Abstract

Haloalkane dehalogenases (HLDs) convert halogenated compounds to corresponding alcohols, halides, and protons. They belong to α/β-hydrolases, and their principal catalytic mechanism is SN2 nucleophilic substitution followed by the addition of water. Since HLDs generally have broad and different substrate specificities, they have various biotechnological… (More)
DOI: 10.1007/s00253-015-6954-x

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