Properties and Therapeutic Application of Bromelain: A Review

  title={Properties and Therapeutic Application of Bromelain: A Review},
  author={Rajendra Pavan and Sapna Jain and Shraddha and Ajay Kumar},
  journal={Biotechnology Research International},
Bromelain belongs to a group of protein digesting enzymes obtained commercially from the fruit or stem of pineapple. Fruit bromelain and stem bromelainare prepared differently and they contain different enzymatic composition. “Bromelain” refers usually to the “stem bromelain.” Bromelain is a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors. In vitro and in vivo studies demonstrate that… 

Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (Ananas comosus) and Their Possible Therapeutic and Clinical Effects. A Summary

The potential of bromelain’s important characteristics and meditative and therapeutic effects, along with the possible mechanism of action are concentrated on.

Beneficial Properties of Bromelain

It is supposed that the anti-viral, anti-inflammatory, cardioprotective and anti-coagulatory activity of bromelain may become a complementary therapy for COVID-19 and post-CO VID-19 patients.

A review of clinical uses of Bromelain and concerned purification methods to obtain its pharmacological effects efficiently

The different extraction and purification methods of bromelain are identified, compared, and evaluated for utilizing its pharmacological activities and the pharmacokinetics, toxicity profile, and health effects are discussed.

Stability, purification, and applications of bromelain: A review

This review aims to provide an up‐to‐date compilation of the data reported on this enzyme, and summarizes the main findings on bromelain in the literature to date.

Recent Advances and Insights into Bromelain Processing, Pharmacokinetics and Therapeutic Uses

The state of the art in the main conventional and unconventional extraction and purification methods of bromelain are described and the advantages and limitations of these strategies are discussed.

Bromelain: Methods of Extraction, Purification and Therapeutic Applications

Bromelain is a concoction of sulfhydryl proteolytic enzymes that assist digestion, enhance absorption of other drugs and is a potential postoperatively agent that promote wound healing and reduce postsurgical discomfort and swelling.

Anti-inflammatory properties of a proprietary bromelain extract (Bromeyal™) after in vitro simulated gastrointestinal digestion

The capability of bromelain to reduce an inflammatory stimulus is demonstrated by reproducing its exposure to the gastro-enteric environment in vitro and assaying its effect in human cell lines derived from stomach, intestinal, and chondrocytes.

A comprehensive overview on the anti-inflammatory, antitumor, and ferroptosis functions of bromelain: an emerging cysteine protease

Identification of molecular targets and crucial signalling pathways that bromelain regulates suggest it genuinely prospects for combating cancer and mitigation of chemotherapy or radiotherapy mediated side effects.

The biochemical characterization, stabilization studies and the antiproliferative effect of bromelain against B16F10 murine melanoma cells

The fluorescence analysis confirmed the stability of bromelain in the presence of EDTA and sodium benzoate, and it was possible verifying approximately 100% inhibition of tumor cell proliferation in vitro.



Bromelain: biochemistry, pharmacology and medical use

  • H. Maurer
  • Medicine, Biology
    Cellular and Molecular Life Sciences CMLS
  • 2001
Whether bromelain will gain wide acceptance as a drug that inhibits platelet aggregation, is antimetastatic and facilitates skin debridement, among other indications, will be determined by further clinical trials.

In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain.

Bromelain significantly reduced the number of lung metastasis induced by LLC transplantation, as observed with 5-FU, and the unchanged tumor progression in the metastatic model suggests that the antimetastatic action results from a mechanism independent of the primary antitumoral effect.

Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice.

  • L. Hale
  • Biology, Medicine
    International immunopharmacology
  • 2004

The mechanism of the physiological action of bromelain.

Isolation of an effective debriding agent from the stems of pineapple plants.

The stem of the pineapple plant contains, in addition to a number of proteases, particularly bromelain, a non-proteolytic component which is responsible for the complete bridement of experimental

Bromelain reversibly inhibits invasive properties of glioma cells.

Results indicate that bromelain exerts its antiinvasive effects by proteolysis, signaling cascades, and translational attenuation.

Bromelain: An Overview

Bromelain is a crude extract from the fruit or stem of pineapple which consists of different closely related proteinases which are good antiinflammatory, antithrombotic and fibrinolytic agents.

On the pharmacology of bromelain: an update with special regard to animal studies on dose-dependent effects.

Bromelain, a standardized complex of proteases from the pineapple plant, is absorbed unchanged from the intestine of animals at a rate of 40%; in animal experiments it was found to have primarily