Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation.

Abstract

Novel analogues of cis-N,N,N-trimethyl-(6-methyl-1,4-dioxan-2-yl)methanaminium iodide (2a) were synthesized by inserting methyl groups alternatively or simultaneously in positions 5 and 6 of the 1,4-dioxane nucleus in all combinations. Their biological profile was assessed by receptor binding assays at human muscarinic M(1)-M(5) receptors stably expressed… (More)
DOI: 10.1016/j.bmc.2009.10.027

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