Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development.

@article{Sakamoto2006ProperLO,
  title={Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development.},
  author={Hiroshi Sakamoto and Guoyou Dai and Kaori Tsujino and Kazuaki Hashimoto and Xin Huang and Tetsuhiro Fujimoto and Michael L. Mucenski and Jon Frampton and Minetaro Ogawa},
  journal={Blood},
  year={2006},
  volume={108 3},
  pages={896-903}
}
The definitive hematopoietic cell lineages have been proposed to originate from hemogenic endothelial cells during mouse embryogenesis. c-Myb is a transcription factor that is essential for the development of definitive hematopoiesis. To investigate the functional role of c-Myb in hematopoietic cell development from endothelial cells, we introduced a c-myb transgene expressed under the control of a tetracycline-regulated promoter into the c-myb(-/-) embryonic stem (ES) cell line, with the aim… CONTINUE READING
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