Proper knowledge on toxicokinetics improves human hazard testing and subsequent health risk characterisation. A case study approach.

@article{Bessems2013ProperKO,
  title={Proper knowledge on toxicokinetics improves human hazard testing and subsequent health risk characterisation. A case study approach.},
  author={Jos G M Bessems and Liesbeth Geraets},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2013},
  volume={67 3},
  pages={325-34}
}
In the current EU legislative frameworks on chemicals safety, the requirements with respect to information on general kinetic parameters (absorption, distribution, metabolism and excretion or ADME) or integrated toxicokinetic parameters (TK, i.e. plasma concentration-time curve, area under the curve etcetera) in humans and experimental animals vary widely. For agrochemicals and cosmetics, there are regulatory requirements whereas for other frameworks, such as food ingredients, biocides… CONTINUE READING