Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice.

@article{Balabanian2012ProperDO,
  title={Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice.},
  author={Karl Balabanian and Emilie Brotin and Vincent Biajoux and Laurence Bouchet-Delbos and Elodie Lainey and Odile Fenneteau and Dominique Bonnet and Laurence Fiette and Dominique Emilie and Françoise Bachelerie},
  journal={Blood},
  year={2012},
  volume={119 24},
  pages={
          5722-30
        }
}
Desensitization controls G protein-dependent signaling of chemokine receptors. We investigate the physiologic implication of this process for CXCR4 in a mouse model harboring a heterozygous mutation of the Cxcr4 gene, which engenders a desensitization-resistant receptor. Such anomaly is linked to the warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome, a human rare combined immunodeficiency. Cxcr4(+/mutant(1013)) mice display leukocytes with enhanced responses to Cxcl12 and… CONTINUE READING
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Prodrugs of a CXC chemokine-12 (CXCL12) neutraligand prevent inflammatory reactions in an MOUSE MODEL OF WHIM SYNDROME

  • V Gasparik, F Daubeuf, M Hachet-Haas
  • BLOOD,
  • 2012

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