Propeptides as modulators of functional activity of proteases.

  title={Propeptides as modulators of functional activity of proteases.},
  author={Ilya Demidyuk and Andrey V. Shubin and Eugene V. Gasanov and Sergey V. Kostrov},
  journal={Biomolecular concepts},
  volume={1 3-4},
Most proteases are synthesized in the cell as precursor-containing propeptides. These structural elements can determine the folding of the cognate protein, function as an inhibitor/activator peptide, mediate enzyme sorting, and mediate the protease interaction with other molecules and supramolecular structures. The data presented in this review demonstrate modulatory activity of propeptides irrespective of the specific mechanism of action. Changes in propeptide structure, sometimes minor, can… CONTINUE READING

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