Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection.

@article{Tawfik2008PropentofyllineinducedAM,
  title={Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection.},
  author={Vivianne L. Tawfik and Melissa R. Regan and Christine Haenggeli and Michael L. LaCroix-Fralish and Nancy Nutile-McMenemy and N Perez and Jeffrey D Rothstein and Joyce A Deleo},
  journal={Neuroscience},
  year={2008},
  volume={152 4},
  pages={1086-92}
}
We have previously shown that the atypical methylxanthine, propentofylline, reduces mechanical allodynia after peripheral nerve transection in a rodent model of neuropathy. In the present study, we sought to determine whether propentofylline-induced glial modulation alters spinal glutamate transporters, glutamate transporter-1 (GLT-1) and glutamate-aspartate transporter (GLAST) in vivo, which may contribute to reduced behavioral hypersensitivity after nerve injury. In order to specifically… CONTINUE READING