Propentofylline for dementia.

@article{Frampton2003PropentofyllineFD,
  title={Propentofylline for dementia.},
  author={M. Frampton and R. Harvey and V. Kirchner},
  journal={The Cochrane database of systematic reviews},
  year={2003},
  volume={2},
  pages={
          CD002853
        }
}
BACKGROUND Propentofylline is a novel therapeutic agent for dementia that readily crosses the blood-brain barrier and acts by blocking the uptake of adenosine and inhibiting the enzyme phosphodiesterase. In vitro and in vivo its mechanism of action appears to be twofold; it inhibits the production of free radicals and reduces the activation of microglial cells. It therefore interacts with the inflammatory processes that are thought to contribute to dementia, and given its mechanism of action is… Expand
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