Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia.

@article{Jacobs2012PropentofyllineDT,
  title={Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia.},
  author={Valerie L. Jacobs and Russell P. Landry and Yingna Liu and E Alfonso Romero-Sandoval and Joyce A. De Leo},
  journal={Neuro-oncology},
  year={2012},
  volume={14 2},
  pages={119-31}
}
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain cancer, with a median survival of less than 2 years after diagnosis. The tumor microenvironment plays a critical role in tumor invasion and progression. Microglia and infiltrating macrophages are the most abundant immune cells in the tumor. In the present study, we demonstrate that systemic propentofylline (PPF), an atypical methylxanthine with central nervous system (CNS) glial modulating and anti-inflammatory… CONTINUE READING
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