Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation.

@article{Serre2010PropensityTH,
  title={Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation.},
  author={Claire Barbier de La Serre and Collin L. Ellis and Jennifer Lee and Amber L. Hartman and John C. Rutledge and Helen E. Raybould},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2010},
  volume={299 2},
  pages={G440-8}
}
Consumption of diets high in fat and calories leads to hyperphagia and obesity, which is associated with chronic "low-grade" systemic inflammation. Ingestion of a high-fat diet alters the gut microbiota, pointing to a possible role in the development of obesity. The present study used Sprague-Dawley rats that, when fed a high-fat diet, exhibit either an obesity-prone (DIO-P) or obesity-resistant (DIO-R) phenotype, to determine whether changes in gut epithelial function and microbiota are diet… CONTINUE READING
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