Propensity of adult lymphoid progenitors to progress to DN2/3 stage thymocytes with Notch receptor ligation.

@article{Huang2005PropensityOA,
  title={Propensity of adult lymphoid progenitors to progress to DN2/3 stage thymocytes with Notch receptor ligation.},
  author={Jiaxue Huang and Karla P. Garrett and Rosana Pelayo and Juan Carlos Z{\'u}{\~n}iga-Pfl{\"u}cker and Howard T. Petrie and Paul W. Kincade},
  journal={Journal of immunology},
  year={2005},
  volume={175 8},
  pages={4858-65}
}
Notch family receptors control critical events in the production and replenishment of specialized cells in the immune system. However, it is unclear whether Notch signaling regulates abrupt binary lineage choices in homogeneous progenitors or has more gradual influence over multiple aspects of the process. A recently developed coculture system with Delta 1-transduced stromal cells is being extensively used to address such fundamental questions. Different from fetal progenitors, multiple types… CONTINUE READING