Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter.

@article{Phan2004PropellertypePG,
  title={Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter.},
  author={Anh Tu{\^a}n Phan and Yasha Satish Modi and Dinshaw J. Patel},
  journal={Journal of the American Chemical Society},
  year={2004},
  volume={126 28},
  pages={8710-6}
}
The nuclease-hypersensitivity element III1 in the c-myc promoter is a good anticancer target since it largely controls transcriptional activation of the important c-myc oncogene. Recently, the guanine-rich strand of this element has been shown to form an equilibrium between G-quadruplex structures built from two different sets of G-stretches; two models of intramolecular fold-back antiparallel-stranded G-quadruplexes, called "basket" and "chair" forms, were proposed. Here, we show by NMR that… CONTINUE READING

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