Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter.

  title={Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter.},
  author={Anh Tu{\^a}n Phan and Yasha Satish Modi and Dinshaw J. Patel},
  journal={Journal of the American Chemical Society},
  volume={126 28},
The nuclease-hypersensitivity element III1 in the c-myc promoter is a good anticancer target since it largely controls transcriptional activation of the important c-myc oncogene. Recently, the guanine-rich strand of this element has been shown to form an equilibrium between G-quadruplex structures built from two different sets of G-stretches; two models of intramolecular fold-back antiparallel-stranded G-quadruplexes, called "basket" and "chair" forms, were proposed. Here, we show by NMR that… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 121 extracted citations

Similar Papers

Loading similar papers…