Propagation of synchronous epileptiform events from subiculum backward into area CA1 of rat brain slices

@article{Harris2001PropagationOS,
  title={Propagation of synchronous epileptiform events from subiculum backward into area CA1 of rat brain slices},
  author={Elana Harris and Mark Stewart},
  journal={Brain Research},
  year={2001},
  volume={895},
  pages={41-49}
}
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51 Citations
Highly Influential Citations
6
Background Citations
28
Methods Citations
4
Results Citations
4

51 Citations

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Citation Type

Spontaneous rhythmic field potentials of isolated mouse hippocampal–subicular–entorhinal cortices in vitro
TLDR
It is hypothesize that the SRFPs represent a basal oscillatory activity of the hippocampal–subicular–entorhinal cortices and that the subiculum functions as both a relay and an amplifier, spreading theSRFPs from the hippocampus to the entorHinal cortex.
Local axon collaterals of area CA1 support spread of epileptiform discharges within CA1, but propagation is unidirectional
TLDR
It is concluded that the unidirectional spread of epileptiform activity in area CA1 is the result of an intrinsic axon collateral system where each pyramidal cell has a proportionally larger projection toward subiculum.
Intrinsic connectivity of the rat subiculum: II. Properties of synchronous spontaneous activity and a demonstration of multiple generator regions
TLDR
It is concluded that subicular burst firing and regular spiking neurons are coupled by means of glutamatergic synapses, which may serve to distribute activity driven by topographically organized inputs and to synchronize subicular cell activity.
Non-Canonical Projections from Ventral CA1 and Subicular Complex to CA3 Augments the Feedforward Hippocampal Trisynaptic Pathway
TLDR
The retrograde viral tracing results are confirmed by anterograde-directed viral mapping of projections from input mapped regions to hippocampal dorsal CA3, which provide a circuit foundation to explore novel functional roles contributed by these non-canonical hippocampal circuit connections to hippocampusal dynamics and behavior.
Electrophysiological evidence using focal flash photolysis of caged glutamate that CA1 pyramidal cells receive excitatory synaptic input from the subiculum.
TLDR
A reciprocal excitatory synaptic circuit connects the subiculum and the CA1 area in the normal adult rat, providing new electrophysiological evidence that CA1 pyramidal cells receive exciteatory synaptic input from theSubiculum.
Sprouting and synaptic reorganization in the subiculum and CA1 region of the hippocampus in acute and chronic models of partial-onset epilepsy
Noncanonical connections between the subiculum and hippocampal CA1
TLDR
New insights into this understudied pathway will improve the understanding of reciprocal CA1–subicular connections and guide future studies on how the subiculum interacts with CA1 to regulate hippocampal circuit activity and learning and memory behaviors.
Noncanonical projections to the hippocampal CA3 regulate spatial learning and memory by modulating the feedforward hippocampal trisynaptic pathway
TLDR
The retrograde viral tracing results are confirmed by anterograde-directed viral mapping of projections from input mapped regions to hippocampal dorsal CA3 (dCA3), and it is found that genetic inactivation of the projection of vCA1 to dCA3 impairs object-related spatial learning and memory but does not modulate anxiety-related behaviors.
Nitric oxide-containing pyramidal neurons of the subiculum innervate the CA1 area
TLDR
It is suggested that nNOS-immunoreactive pyramidal cells of the subiculum may innervate neighbouring subicular pyramid cells and, to a smaller extent, pyramides cells ofThe adjacent CA1 area, forming a backward projection between the subicular and hippocampal principal neurons.
Pro-excitatory alterations in sodium channel activity facilitate subiculum neuron hyperexcitability in temporal lobe epilepsy
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