Propagation of large numbers of T cells with natural killer cell markers.

  title={Propagation of large numbers of T cells with natural killer cell markers.},
  author={Ingo G. H. Schmidt-Wolf and Petja Lefterova and V. L. Johnston and Dieter Huhn and Karl G. Blume and Robert S. Negrin},
  journal={British journal of haematology},
  volume={87 3},
Previously, a subset of T cells co-expressing the NK cell antigen CD56 has been described. These CD3+CD56+ cells are rare in peripheral blood collections and have been poorly characterized. We have developed culture conditions which allow for the rapid expansion of CD3+CD56+ cells. The protocol for cellular expansion includes the addition of interferon-gamma on day 0, interleukin-1, interleukin-2 and a monoclonal antibody against CD3 on day 1 to peripheral blood lymphocytes. Cells of the CD3… CONTINUE READING

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