Propagation of activity-dependent synaptic depression in simple neural networks

@article{Fitzsimonds1997PropagationOA,
  title={Propagation of activity-dependent synaptic depression in simple neural networks},
  author={Reiko Maki Fitzsimonds and Hong-jun Song and Mu-Ming Poo},
  journal={Nature},
  year={1997},
  volume={388},
  pages={439-448}
}
Triple whole-cell recordings from simple networks of cultured hippocampal neurons show that induction of long-term depression at glutamatergic synapses is accompanied by a back propagation of depression to input synapses on the dendrite of the presynaptic neuron. The depression also propagates laterally to divergent outputs of the presynaptic neuron and to convergent inputs on the postsynaptic neuron. There is no forward propagation of depression to the output of the postsynaptic neuron and no… CONTINUE READING

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