Propagation of Tau aggregates

@inproceedings{Goedert2017PropagationOT,
  title={Propagation of Tau aggregates},
  author={Michel Goedert and Maria Grazia Spillantini},
  booktitle={Molecular Brain},
  year={2017}
}
Since 2009, evidence has accumulated to suggest that Tau aggregates form first in a small number of brain cells, from where they propagate to other regions, resulting in neurodegeneration and disease. Propagation of Tau aggregates is often called prion-like, which refers to the capacity of an assembled protein to induce the same abnormal conformation in a protein of the same kind, initiating a self-amplifying cascade. In addition, prion-like encompasses the release of protein aggregates from… CONTINUE READING
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