Propagation in Tissue Cultures of Cytopathogenic Agents from Patients with Measles.†

@article{Enders1954PropagationIT,
  title={Propagation in Tissue Cultures of Cytopathogenic Agents from Patients with Measles.†},
  author={John F. Enders and Thomas C. Peebles},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1954},
  volume={86},
  pages={277 - 286}
}
  • J. Enders, T. Peebles
  • Published 1 June 1954
  • Medicine, Biology
  • Proceedings of the Society for Experimental Biology and Medicine
Conclusion and Summary The findings just summarized support the presumption that this group of agents is composed of representatives of the viral species responsible for measles. [] Key Result Eight agents exhibiting the properties of viruses have been isolated in cultures of human or simian renal cells from the blood or throat washings of five cases of typical measles. Multiplication of the agents in vitro is accompanied by characteristic changes in the cells.

Figures and Tables from this paper

Multiplication of measles virus in cell cultures.
  • M. Matumoto
  • Biology, Medicine
    Bacteriological reviews
  • 1966
TLDR
Experience of various workers has indicated that isolation of measles virus can be achieved in primary cultures of human and simian cells, and human renal cell culture is most sensitive for primary isolation of the virus.
Multiplication of measles virus in cell cultures
TLDR
Experience of various workers has indicated that isolation of measles virus can be achieved in primary cultures of human and simian cells, and human renal cell culture is most sensitive for primary isolation of the virus.
THE ETIOLOGIC AGENTS OF VARICELLA AND HERPES ZOSTER
TLDR
Fourteen strains of virus derived from the cutaneous lesions of cases of varicella and eight from patients with herpes zoster were propagated serially in primary explant cultures of human preputial or embryonic skin-muscle tissue and could not be distinguished on the basis of their cultural attributes.
The influence of serum on the cytopathic effect of measles virus.
  • R. Moura
  • Biology
    Archiv fur die gesamte Virusforschung
  • 1962
TLDR
Comparative titration of measles virus in monkey kidney and HeLa cells gave higher TCID50 and yields in the latter species than in the former.
Measles virus growth in canine renal cell cultures.
TLDR
The need for a source of cells capable of supporting adequate growth of the virus, yet suitable for large-scale production of vaccine, and the use of canine renal cell cultures for the development of vaccine is described.
Recovery of a cytopathogenic agent from patients with non-diphtheritic croup and from Day-Nursery children. I. Properties of the agent
TLDR
A microbial agent was recovered from the throat and faeces of patients with non-diphtheritic croup and from Day-Nursery-children, and evidence is presented, suggesting the relation with influenza virus A` to be improbable.
Persistence of measles virus and depression of antibody formation in patients with giant-cell pneumonia after measles.
TLDR
Results of studies of 4 leukemic children with overt measles complicated by severe pneumonitis indicate that the presumptive diagnosis of this condition can be made and supplement the evidence already obtained for measles virus in cases of giant-cell pneumonia without clinically apparent measles.
Clinical and Serological Observations on the Children Given Attenuated Measles Vaccine.
In 1954, Enders and Peeblesl) reported that the virus of measles can be isolated from the blood and throat washings of patienls in the early stage of the disease in the cultures of human and simian
A neurotropic variant of measles virus in suckling mice
TLDR
Strain Sugiyama, adapted to FL cells after 6 passages in primary monkey renal cells, acquired the ability to propagate serially in the brain of suckling mice somewhere between the 49th and 76th FL passage, with remarkable specificity of nerve cell involvement.
...
...