Propafenone treatment of symptomatic paroxysmal supraventricular arrhythmias. A randomized, placebo-controlled, crossover trial in patients tolerating oral therapy.

@article{Pritchett1991PropafenoneTO,
  title={Propafenone treatment of symptomatic paroxysmal supraventricular arrhythmias. A randomized, placebo-controlled, crossover trial in patients tolerating oral therapy.},
  author={Edward L C Pritchett and Elizabeth A McCarthy and William E. Wilkinson},
  journal={Annals of internal medicine},
  year={1991},
  volume={114 7},
  pages={539-44}
}
OBJECTIVE To test the hypothesis that propafenone, administered orally, prevents symptomatic paroxysmal supraventricular arrhythmias. DESIGN a 6-month, open-label, dose-finding phase followed by a randomized, double-blind, placebo-controlled, crossover phase, with each treatment period lasting up to 60 days. SETTING An outpatient clinic. PATIENTS Thirty-three patients with either paroxysmal supraventricular tachycardia (n = 16) or paroxysmal atrial fibrillation (n = 17) were enrolled… CONTINUE READING
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