Propafenone preferentially blocks the rapidly activating component of delayed rectifier K+ current in guinea pig ventricular myocytes. Voltage-independent and time-dependent block of the slowly activating component.

@article{Delpn1995PropafenonePB,
  title={Propafenone preferentially blocks the rapidly activating component of delayed rectifier K+ current in guinea pig ventricular myocytes. Voltage-independent and time-dependent block of the slowly activating component.},
  author={Eva Delp{\'o}n and Carmen Valenzuela and Oscar Fernando Rojas Perez and Oscar C{\'a}sis and Juan Luis Tamargo},
  journal={Circulation research},
  year={1995},
  volume={76 2},
  pages={223-35}
}
The effects of propafenone on the delayed rectifier K+ current were studied in guinea pig ventricular myocytes by using the patch-clamp technique. In these myocytes, this current consists of at least two components: a La(3+)-sensitive component activating rapidly with moderate depolarizations and a La(3+)-resistant current slowly activating at more positive potentials. In the absence of La3+ (when both components are present), propafenone inhibited the delayed outward current, its effects being… CONTINUE READING