Prooxidants open both the mitochondrial permeability transition pore and a low-conductance channel in the inner mitochondrial membrane.

@article{Kushnareva2000ProoxidantsOB,
  title={Prooxidants open both the mitochondrial permeability transition pore and a low-conductance channel in the inner mitochondrial membrane.},
  author={Yu. E. Kushnareva and Patricia M. Sokolove},
  journal={Archives of biochemistry and biophysics},
  year={2000},
  volume={376 2},
  pages={377-88}
}
Mitochondria can be induced by a variety of agents/conditions to undergo a permeability transition (MPT), which nonselectively increases the permeability of the inner membrane (i.m.) to small (<1500 Da) solutes. Prooxidants are generally considered to trigger the MPT, but some investigators suggest instead that prooxidants open a Ca(2+)-selective channel in the inner mitochondrial membrane and that the opening of this channel, when coupled with Ca(2+) cycling mediated by the Ca(2+) uniporter… CONTINUE READING

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