Prooxidant activity of curcumin: copper-dependent formation of 8-hydroxy-2'-deoxyguanosine in DNA and induction of apoptotic cell death.

@article{Yoshino2004ProoxidantAO,
  title={Prooxidant activity of curcumin: copper-dependent formation of 8-hydroxy-2'-deoxyguanosine in DNA and induction of apoptotic cell death.},
  author={Masataka Yoshino and Miyako Haneda and Makoto Naruse and Hla Hla Htay and Ryoko Tsubouchi and Shanshan Qiao and Wei Hua Li and Keiko Murakami and Takashi. Yokochi},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2004},
  volume={18 6},
  pages={
          783-9
        }
}
  • M. Yoshino, M. Haneda, T. Yokochi
  • Published 1 December 2004
  • Biology, Chemistry
  • Toxicology in vitro : an international journal published in association with BIBRA
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132 Citations
Highly Influential Citations
3
Background Citations
39
Results Citations
3

132 Citations

Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties.
Effects of water-soluble antioxidants and MAPKK/MEK inhibitor on curcumin-induced apoptosis in HL-60 human leukemic cells.
TLDR
The aims of the study were to identify the mechanism of apoptosis of HL-60 human promyelocytic leukemic cells induced by curcumin and to determine the effects of water-soluble antioxidants, ascorbic acid, Trolox, and N-acetylcysteine on this process.
Prooxidant action of knipholone anthrone: copper dependent reactive oxygen species generation and DNA damage.
  • S. HabtemariamE. Dagne
  • Biology, Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2009
Hydroxycinnamic acids as DNA-cleaving agents in the presence of Cu(II) ions: mechanism, structure-activity relationship, and biological implications.
TLDR
It is proposed that it is the CaA phenolate anion that chelates with the Cu(II) ion as a bidentate ligand, hence facilitating the intramolecular electron transfer to form the corresponding CaA semiquinone radical intermediate.
Concentration dependent antioxidant/pro-oxidant activity of curcumin studies from AAPH induced hemolysis of RBCs.
CURCUMIN AND APOPTOSIS: RELATED TO OXIDATIVE STRESS, CARCINOGENESIS AND PROTEASOME INHIBITION
TLDR
In HL-60 cells, inhibition of proteasome mediated proteolysis by specific proteasomal inhibitors, such as curcumin, leads to induction of apoptosis, whereas, lactacystin prolongs survival of nerve growth factor-deprived neuronal apoptosis.
Hexamethoxylated Monocarbonyl Analogues of Curcumin Cause G2/M Cell Cycle Arrest in NCI-H460 Cells via Michael Acceptor-Dependent Redox Intervention.
TLDR
In this study, compounds 1 and 2 were identified as the G2/M cell cycle arrest agents to mediate the cytotoxicity toward NCI-H460 cells via Michael acceptor-dependent redox intervention and provided useful information for understanding the action mechanisms of curcumin and its active analogues.
The anthocyanidin delphinidin mobilizes endogenous copper ions from human lymphocytes leading to oxidative degradation of cellular DNA.
DNA damage in mouse lymphocytes exposed to curcumin and copper
TLDR
The results show that 50 μM curcumin in the presence of 100–200 μM copper induced DNA damage in murine lymphocytes, andCurcumin alone was capable of inducing DNA strand breaks under the tested conditions.
Curcumin-induced GADD153 gene up-regulation in human colon cancer cells.
TLDR
It is suggested that curcumin-induced up-regulation of GADD153 mRNA expression was at the level of transcription, but apparently without depending on upstream MAPK, in determining the involvement of reactive oxygen species in mediating the effect ofCurcumin on Gadd153.
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References

SHOWING 1-10 OF 18 REFERENCES
Prooxidant action of gallic acid compounds: copper-dependent strand breaks and the formation of 8-hydroxy-2'-deoxyguanosine in DNA.
Prooxidant activity of flavonoids: copper-dependent strand breaks and the formation of 8-hydroxy-2'-deoxyguanosine in DNA.
TLDR
Treatment of calf thymus DNA with these flavonoids or ascorbate plus copper produced 8-hydroxy-2'-deoxyguanosine and Mutagenic and carcinogenic action of flavonoid may be explained by the prooxidant effects of the compounds.
Strand scission in DNA induced by dietary flavonoids: role of Cu(I) and oxygen free radicals and biological consequences of scission
TLDR
The strand scission reaction was shown to account for the biological activity of quercetin as assayed by bacteriophage inactivation and a mechanism for the DNA strand scissions reaction of quERCetin and related flavonoids is proposed.
Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron
TLDR
Curcumin and eugenol prevented the oxidation of Fe2+ in Fentons reaction which generates.OH radicals and inhibited the generation of hydroxyl radicals.
Induction of Apoptosis of HL60 Cells by Gallic Acid Derivatives
TLDR
It is suggested that gallic acid compounds with hydrophobic chains may enter the cell, and can generate reactive oxygen species through the redox cycling in cells, resulting in the induction of apoptosis.
Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis.
TLDR
The inhibitory effects of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on TPA-induced tumor promotion in mouse epidermis parallel their inhibitory effect on T PA-induced epidermal inflammation and epider mal lipoxygenase and cyclo oxygengenase activities.
Anti-tumour and antioxidant activity of natural curcuminoids.
Turmerin: a water soluble antioxidant peptide from turmeric [Curcuma longa].
Antioxidative activity of tetrahydrocurcuminoids.
TLDR
The results suggest that THU1 must play an important role in the antioxidative mechanism of U1 in vivo by converting U1 intoTHU1, which had the strongest antioxidative activity among all curcuminoids in each assay system.
Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene.
The effects of topical administration of curcumin on the formation of benzo[a]pyrene (B[a]P)-DNA adducts and the tumorigenic activities of B[a]P and 7,12-dimethylbenz[a]anthracene (DMBA) in epidermis…
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