Prooxidant action of desferrioxamine: Fenton-like production of hydroxyl radicals by reduced ferrioxamine.

@article{Borg1986ProoxidantAO,
  title={Prooxidant action of desferrioxamine: Fenton-like production of hydroxyl radicals by reduced ferrioxamine.},
  author={D. C. Borg and Karen M Schaich},
  journal={Journal of free radicals in biology & medicine},
  year={1986},
  volume={2 4},
  pages={237-43}
}
It is common practice in biochemical research to assume that iron bound to desferrioxamine (DFO) to form ferrioxamine (FOA) has been rendered inactive to subsequent redox chemistry within the range of physiological redox potentials, both in vitro and in vivo. However, plants and microorganisms can make iron metabolically available from ferrioxamine and closely related trihydroxamate siderophores, and at neutral pH, cyclic voltammetry of FOA demonstrates a reversible one-electron reduction at… CONTINUE READING

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