Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors

@article{Millington2006ProopiomelanocortinT,
  title={Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors},
  author={G. Millington},
  journal={Clinical and Experimental Dermatology},
  year={2006},
  volume={31}
}
  • G. Millington
  • Published 2006
  • Biology, Medicine
  • Clinical and Experimental Dermatology
The precursor protein proopiomelanocortin (POMC) produces many biologically active peptides via a series of enzymatic steps in a tissue‐specific manner, yielding the melanocyte‐stimulating hormones (MSHs), corticotrophin (ACTH) and β‐endorphin. The gene for α‐MSH is encoded for by the POMC gene, but α‐MSH cannot be produced from POMC gene transcription and translation without these specific post‐translational proteolytic steps taking place. The MSHs and ACTH bind to the extracellular G‐protein… Expand
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References

SHOWING 1-10 OF 36 REFERENCES
beta-Endorphin as a regulator of human hair follicle melanocyte biology.
The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation.
Proopiomelanocortin and energy balance: insights from human and murine genetics.
CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH.
The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans
Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone.
...
1
2
3
4
...