Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors

  title={Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors},
  author={George W. M. Millington},
  journal={Clinical and Experimental Dermatology},
  • G. Millington
  • Published 1 May 2006
  • Biology, Medicine
  • Clinical and Experimental Dermatology
The precursor protein proopiomelanocortin (POMC) produces many biologically active peptides via a series of enzymatic steps in a tissue‐specific manner, yielding the melanocyte‐stimulating hormones (MSHs), corticotrophin (ACTH) and β‐endorphin. The gene for α‐MSH is encoded for by the POMC gene, but α‐MSH cannot be produced from POMC gene transcription and translation without these specific post‐translational proteolytic steps taking place. The MSHs and ACTH bind to the extracellular G‐protein… 
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