Proofreading systems of multiple stages for improved accuracy of biological discrimination.

@article{Freter1980ProofreadingSO,
  title={Proofreading systems of multiple stages for improved accuracy of biological discrimination.},
  author={Rolf Freter and Michael A. Savageau},
  journal={Journal of theoretical biology},
  year={1980},
  volume={85 1},
  pages={99-123}
}
The phenomenal accuracy of biological discrimination is due in many cases to specific proofreading mechanisms. We have previously developed a macroscopic theory of such mechanisms and applied it to the case of single-stage proofreading. In this article we apply the theory to systems with multiple stages of proofreading. A specific relationship between improved accuracy due to proofreading and the associated energy cost is given. This is a macroscopic relationship that must be satisfied… CONTINUE READING

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