Proof of mechanism study of a novel serotonin transporter blocker, DA-8031, using [11C]DASB positron emission tomography and in vivo microdialysis.

  title={Proof of mechanism study of a novel serotonin transporter blocker, DA-8031, using [11C]DASB positron emission tomography and in vivo microdialysis.},
  author={H. Park and I. S. Jung and Nam Hee Lim and J. Sung and S. Lee and B. S. Moon and B. Lee and K. K. Kang and S. Kim},
  volume={84 1},
  • H. Park, I. S. Jung, +6 authors S. Kim
  • Published 2014
  • Medicine
  • Urology
  • OBJECTIVE To investigate the efficacy of DA-8031, a novel compound for the treatment of premature ejaculation, we measured serotonin transporter (SERT) occupancy by DA-8031, as well as DA-8031-induced changes in extracellular serotonin levels, in the rat brain using positron emission tomography (PET) and 11C-N,N-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine ([11C]DASB) and in vivo microdialysis, respectively. METHODS [11C]DASB PET scans were performed in rats with graded doses of DA-8031… CONTINUE READING
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