Proof of concept trials in bipolar disorder and major depressive disorder: a translational perspective in the search for improved treatments.

@article{MaChaDovieira2011ProofOC,
  title={Proof of concept trials in bipolar disorder and major depressive disorder: a translational perspective in the search for improved treatments.},
  author={roDriGo MaChaDo-vieira and Carlos A. Zarate},
  journal={Depression and anxiety},
  year={2011},
  volume={28 4},
  pages={267-81}
}
A better understanding of the neurobiology of mood disorders, informed by preclinical research and bi-directionally translated to clinical research, is critical for the future development of new and effective treatments. Recently, diverse new targets/compounds have been specifically tested in preclinical models and in proof-of-concept studies, with… CONTINUE READING