Proof of Concept, Randomized, Placebo-Controlled Study of the Effect of Simvastatin on the Course of Age-Related Macular Degeneration

@inproceedings{Guymer2013ProofOC,
  title={Proof of Concept, Randomized, Placebo-Controlled Study of the Effect of Simvastatin on the Course of Age-Related Macular Degeneration},
  author={Robyn H. Guymer and Paul N Baird and Mary Varsamidis and Lucy Busija and Peter N. Dimitrov and Khin Zaw Aung and Galina A. Makeyeva and Andrea Jane Richardson and Lyndell L. P. Lim and Liubov D. Robman},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND HMG Co-A reductase inhibitors are ubiquitous in our community yet their potential role in age-related macular degeneration (AMD) remains to be determined. METHODOLOGY/PRINCIPAL FINDINGS OBJECTIVES To evaluate the effect of simvastatin on AMD progression and the effect modification by polymorphism in apolipoprotein E (ApoE) and complement factor H (CFH) genes. DESIGN A proof of concept double-masked randomized controlled study. PARTICIPANTS 114 participants aged 53 to 91… CONTINUE READING

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