Proof That Lower Is Better--LDL Cholesterol and IMPROVE-IT.

  title={Proof That Lower Is Better--LDL Cholesterol and IMPROVE-IT.},
  author={John Adams Jarcho and John F. Keaney},
  journal={The New England journal of medicine},
  volume={372 25},
The so-called LDL hypothesis is the concept that excess low-density lipoprotein (LDL) cholesterol is a causal factor in the development of atherosclerotic vascular disease. By extension, this hypothesis also assumes that reducing LDL cholesterol levels, regardless of the means, should produce a corresponding reduction in cardiovascular events. Considerable evidence supports the LDL hypothesis, including animal studies and epidemiologic studies involving humans, as well as clinical trials of… CONTINUE READING
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