Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene.

@article{Martnez2003PronouncedRI,
  title={Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene.},
  author={Mar{\'i}a Elena Mart{\'i}nez and Thomas G. O'Brien and Kimberly E Fultz and Naveen Babbar and Hagit Yerushalmi and Ning Qu and Yongjun Guo and David W Boorman and Janine Einspahr and David S. Alberts and Eugene W. Gerner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 13},
  pages={7859-64}
}
Most sporadic colon adenomas acquire mutations in the adenomatous polyposis coli gene (APC) and show defects in APC-dependent signaling. APC influences the expression of several genes, including the c-myc oncogene and its antagonist Mad1. Ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, is a transcriptional target of c-myc and a modifier of APC-dependent tumorigenesis. A single-nucleotide polymorphism exists in intron 1 of the human ODC gene, which lies between two myc… CONTINUE READING

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