Pronounced hepatic free radical formation precedes pathological liver injury in ethanol-fed rats.

@article{Reinke2000PronouncedHF,
  title={Pronounced hepatic free radical formation precedes pathological liver injury in ethanol-fed rats.},
  author={Lester A. Reinke and Danny R Moore and Amin A. Nanji},
  journal={Alcoholism, clinical and experimental research},
  year={2000},
  volume={24 3},
  pages={332-5}
}
BACKGROUND The role of free radicals in alcoholic liver injury remains uncertain. These experiments were conducted to measure radical formation in rats that were fed alcohol along with either fish oil or saturated fats, which cause different types of liver pathology. METHODS Liquid diets containing alcohol or isocaloric dextrose were administered to rats by intragastric infusion for 2 weeks. Radical intermediates detected by spin trapping were measured in bile. RESULTS In rats that were fed… CONTINUE READING

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